Methadone
Methadone Matters: Evolving Community Methadone Treatment of Opiate Addiction
(Paperback) Informa Healthcare 2003-04-03
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i take large amts of morphine for degenrative joint disease of the spine. I hate what it does to me, so my doctor has suggested methadone. I have read the pharmacology on it and im not sure id like it any better.
Morphine Side Effects---
Can be habit forming
Don't drink alcohol
Don't stop suddenly
Respiratory depression this is very important to monitor!
Nausea
Vomiting
Cough suppression
Muscles of bowl and urinary tract
Itchy skin
Methadone Side Effects--
Swelling of face,lips,tongue or throat
Shallow breathing
Hallucinations/confusion
Chest pain/dizziness/fating/fast or pounding heart rate
Trouble breathing/light headed
All this requires immediate medical attention
Anxious/nervous/restless
Insomnia
Weak/ drowses
Dry mouth
Nausea
Vomiting
Diarrhea
Constipation
Loss of appetite
Loss of sex drive
Impotence
Difficulty getting orgasm
ALSO HABIT FORMING
Methadone====
This is used in Europe, Australia, New Zea land and Canada But severely restricted in the USA. Methadone is an opiate against which has series of actions similar to those of morphine and other narcotic meds.
Morphine== this med is designed to release the medication slowly over time. this gives pain relief for 12-24 hours This is an opioid It acts upon specific receptors in the brains and spinal cords of people. To decrease the feeling of pain and to reduce the emotional response to pain. Morphine effectively treats moderate to severe pains.
idle edsel breaks the Methadone Conspiracy story on 1-1-11 in Norfolk Virginia. Basic Pharmacology: How Methadone Works? Part I Introduction by ...
"Is alcohol worse than ecstasy?" is a BBC documentary based on a study by Professor David Nutt, a psycho-pharmacologist at Bristol University and member of the Advisory Council on Misuse of Drugs, published early 2007. He and his team analyzed the evidence of harm caused by 20 drugs. They asked a group of 29 consultant psychiatrists who specialize in addiction to rate the drugs in categories related to physical harm, related to the likelihood of addiction and related to social harms. They also extended the analysis to another group of 16 experts spanning several fields including pharmacology, police, chemistry, forensics, psychiatry and legal services. - IMDB
The ranking:
20 Cathinone (Khat)
19 Amyl nitrite (Poppers)
18 MDMA/ Ecstasy
17 GHB
16 Anabolic steroid
15 Methylphenidate (e.g. Ritalin)
14 LSD/ Acid
13 4-MTA
12 Solvents
11 THC (Cannabis)
10 Buprenophine hydrochloride
9 Nicotine (Tobacco)
8 Amphetamine/ Speed
7 Benzodiazepine (e.g. Valium)
6 Ketamine
5 Alcohol
4 Methadone
3 Barbiturates
2 Cocaine/ Crack cocaine
1 Heroin
For those who have seen this or read the report, what do you think of their rankings?
Aired Feb 5, 2008 - website: http://www.bbc.co.uk/sn/tvradio/programm es/horizon/broadband/tx/drugs/survey/
You can watch it on google video: http://video.google.com/googleplayer.swf ?docId=6108672696241807159
Professor David Nutt at the University of Bristol: http://www.bris.ac.uk/neuroscience/the_n ode/research/groups/pidetails/80
Watch the video or go to the website. It might help explain why they chose that ranking...
I hope you're joking, Ty T. Marijuana is definitely on this list and it's ranking surprised me.
The reasoning of the experts is sound, in that alcohol is more dangerous in general based on the fact that it is far more prevalent so the frequency of abuse related disease, death and injuries is therefore greater. Looking at an individual case, Ecstasy has far more serious medical manifestations and presents similar judgment and coordination problems related to operating a motor vehicle as compared to alcohol, and so from that perspective, Ecstasy is more dangerous to an individual. It should probably be rated as more dangerous than THC, less so than Ketamine. Millions of people use alcohol responsibly on a daily basis without abusing it or suffering detrimental effects. The same cannot be said for Ecstasy.
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Effect of Raltegravir on the Pharmacokinetics of Methadone — J ...
Abstract
A randomized, placebo-controlled, 2-period crossover study in subjects on methadone maintenance therapy was conducted to assess the effect of the HIV-1 integrase inhibitor, raltegravir, on the pharmacokinetics of methadone. Twelve HIV-negative male and female subjects stabilized on an oral methadone program were enrolled. Subjects maintained their prescribed oral doses of methadone throughout the study and, in each of 2 periods, received either 400 mg of raltegravir or matching placebo every 12 hours on days 1 through 10 of each treatment period with a washout of 7 days between periods. Plasma samples for analysis of methadone pharmacokinetics were collected over 24 hours postdose on day 10 of each treatment period. Safety and tolerability were assessed throughout the study. The geometric mean ratio (90% confidence interval) for methadone when administered with raltegravir relative to methadone alone was 1.00 (0.93-1.09) for area under the methadone concentrationtime curve from time 0 to 24 hours and 1.00 (0.94-1.07) for maximal concentration. There were no serious clinical or laboratory adverse experiences. There were no discontinuations due to an adverse experience. Coadministration of raltegravir and methadone is generally well tolerated. Raltegravir has no clinically meaningful effect on methadone pharmacokinetics. No dose adjustment is required for methadone when coadministered with raltegravir.
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