Answers

How long does Methadone take for a person to feel it being that the person is taking 20mg for the first time?

Being that this person hasn't taken this med for months and has only been on 1-2 Oxycodone 5mg/ (325mg acetaminophen) every six hours for two months. Now starting Methadone regularly with Oxy for breakthrough pain. Some say Methadone peaks at three hours but other say it works just fine in 20-30 min. I took it over two and a half hours ago, along with on Oxy, and am barely feeling about 5% relief just now.


Methadone enters the bloodstream w/in mins. You should feel the effects immediately. Sounds like you need your dosage increased.
You said that you just started onMethadonee... i do believe that they will increase the dosage weekly. Taking Oxy really won't do anything for you if you continue w/ themethadonee, because it is an opiate blocker.

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Question about Methadone 10mg?

Hi, I took a 10 mg methadone earlier today. I have NEVER taken anything like this before. I called up poison control and they said 10 mg is alot to take. I thought it was a fairly low dosage. Also they said after 12 hours you start to feel the effects which is really freaking me out! I just want to know when I wont feel nausiated anymore and if this med does peak after 12 hours. I hope someone knows....Im having a panick attack :(

Thanks


I HAVE BEEN ON METHADONE FOR 13 YRS. 120 MG. DAILY. IF YOU HAVE NO TOLERANCE TO OPIATES (PAIN PILLS), YOU WILL GET HIGH. IF YOU HAVE TROUBLE BREATHING GO TO OR CALL AN AMBULANCE. YOU SHOULD BE OK,IF YOU ONLY TOOK 10 MG. PEAK BLOOD LEVEL TAKES ABOUT 4 HRS.THE ONLY THING TO BE CONCERNED WITH IS RESPIRATION.IF YOU HAVE TAKEN NARCOTICS (OPIATES) ON A SOMEWHAT REGULAR BASIS, YOU WILL HAVE A TOLERANCE. ONCE AGAIN,THE THING TO LOOK FOR IS DIFFICULTY BREATHING. IT IS VERY LONG LASTING,UP TO 24 HRS.,BUT SLOWLY WEARS OFF.IF TAKEN WITH A LARGE AMOUNT OF ALCOHOL,BE EXTREMELY CAREFUL TO MONITOR YOUR BREATHING.

Comparing long acting pain meds?

I use a combination of MSContin and Roxicodone for pain....One thing I DO NOT like about MSContin is that it takes 2.5 hours to even START working. This makes it absolutely useless for acute pain....and of course thats what the immediate release is for, but I feel that MSContin is especially bad in that there is absolutely zero relief for 2.5 hours, and then a very strong peak at hour 4 to 6, then a rapid drop off again....it almost seems like doesnt really last much longer than Roxicodone for me, just delayed.

The other issue is that I worry about overdose....I have horrible acute pain from a gallbladder/Odi disorder that has also caused pancreatitis.....so I take my MSContin, but am forced to use additional Roxicodone to stop the acute pain, and then the MSContin kicks in and I feel way too high...Im not trying to get high, I am trying to not be in pain. Waiting 2.5 hours for the MSContin is a no go when you are in horrible pain all the time.

So, what are some other alternatives? I dont do well with Fentanyl. It does not have any mood lifting properties, and in fact causes me to experience agitation and aggression.

Oxycontin would be a good choice, but I cannot afford it because its not generic....I like the Roxicodone because it doesnt make me drowsy like other opiates...I can function on it, unlike the MSContin which makes me drowsy. The time release Oxycodone, namned Oxycontin would be hundreds of dollars a month....No thank you. My copay for generic is 15 dollars.

Does anyone else have experience with other generic options for time release opiates? What about Oramorph or other forms of time release morphine? Do any of them hit you a little faster making them more practical for acute pain in conjunction with your immediate relief? Any other time release options, like time release Demerol?

My doctor has discussed Methadone with me....it sounds like an option. I heard its hard to ween off of, but maybe it wouldnt be so bad due to the fact that I am not on a super high dose....I am on a higher dose, but not like the kinds of doses that drug addicts are on. Anyone have experience with methadone for chronic pain, mixed with oxycodone?

What kind of long acting opiates or opiods do you use, and what is your experience with them?
That is one of the worst answers I have heard in some time. Too bad you are the only one who answered.

I have Crohns. This isnt muscle tension.


It sounds like cost is a huge limiting factor. Unfortunately, most of the delayed release drugs are quite expensive. It also sounds like you have concerns about taking long-acting drugs. What about just using the immediate-release oxycodone around the clock instead of taking anything long-acting at all? Also, I think methadone is an excellent idea. It is really an outstanding drug and takes a little bit of an experienced doctor to manage it. I would also note the when drug addicts take it (methadone maintenance), they only take it once a day, whereas for chronic pain, it is generally taken about 3-4 times per day. If I were you, I would go for the methadone. I am not sure if it more difficult to be weaned off than any other opioid. I have met patients who were incredibly addicted to Oxycontin, Vicodin, and other pain meds.

Medical-addiction Question?

Hey, I'm 26 and have been reliant upon opiates since I was 18. Finally, at 23 and after months of fatigue/sickness, countless attempts at anti-depressants, treatment centers, counseling, and psychiatrists, I began methadone at the Southern Indiana Treatment Center. At first I felt much better, but rather than decrease the dose my levels were increased to "find me a stable dose where I feel semi-normal.". Needless to say I am now on 110 mg of methadone once daily. I still feel crappy half the time and have started realizing that my body, with the way it metabolizes medicine so quickly, may never be OK without it. The peak-and-trough blood serum test suggests my body needs 140. Should I accept the fact that my body will always need opiates? Anyone have any suggestions?


"Should I accept the fact that my body will always need opiates?"
No.

"Anyone have any suggestions?"
Follow your doctor advice. And if you have money, I would suggest to afford hypnotherapy, and maybe pay people to watch you for not using drugs. Well the ideal way would be to spend your money to prevent you to do drugs.

I can't tell you can be back to normal 100%. It depends on how far the drugs did damage. Didn't mean to make downer, but addiction also may past the irreversible point, in which you can't really go back as you were before (the brain)

best natural painkiller?

i have recently been experimenting with herbs and other legal substances for anxiety reasons etc. i have tried kava kava (an interesting little experience, but too much prep work for a short unreliable peak). i have tried ativan (not perscribed to me, made my arms kind of numb but about the same stuff as kava kava). and i also use alcohol sometimes and know it can nullify pain. now all these things do i zombify me, i want to feel sedated ans euphoric.

i have codeine in my possession but want to stay away from opiates and semithythetic opiates. though i might try a completely synthetic like methadone. i hear kratom is a amazing, but is it as strong as it's RX brothers? thank you.


There are reasons to your anxiety; maybe your hormones are out of balance or your Thyroid is over producing Thyroid hormones (again hormonal imbalance), you maybe deficient of specific vitamins and/or minerals, etc.
I would suggest you first go and have your blood tested for them.
Here are a few things you can do & take..
Vitamin B-complex (therapeutic dosage like B50), passiflower tincture,
Valerian root extract, poppy seed extract, Melatonin (an amino acid to help your mind & body to calm down), calcium & magnesium supplements, healthy diet, exercise, direct sunlight, etc...
And also constipation causes mood swings and depression so eat lots of fibers and vegetables.
Good Luck.


What do Methadone Peak and Trough levels Mean? « Janaburson's Blog

 

In patients prescribed methadone to treat opioid addiction, the blood level of methadone peaks at around three hours after dosing. The methadone level is at its lowest at twenty-four hours after the last dose, just before the patient is due for their next dose of daily methadone. We can draw blood at the time of lowest methadone level, called a trough level, just before the next dose is due. Then we can draw blood at the time of the highest concentration of methadone in the blood, called a peak level, at about three hours after the last dose. These numbers provide information about the adequacy of the patient’s dose, though they’re far from definitive.

Usually, patients need to have a trough blood level higher than 200 – 400 ngm/ml to stay out of withdrawal at the end of a dosing cycle. Some patients need higher levels. And a peak level that is more than two times the trough level indicates that the patient is metabolizing methadone quickly, and may need to increase the dose or consider split dosing.

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